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3.2.1 Activation of HSCs via TGF-/Smad and MAPK signaling TGF- is the prototypical pro-fibrogenic cytokine upregulated in nearly all chronic fibrotic disorders

J Neurol 254:16761683

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The notion that abnormal glutathione metabolism could lead to oxidative damage is consistent with studies which demonstrate oxidative damage to proteins and DNA in peripheral blood mononuclear cells and postmortem brain from ASD individuals (106), particularly in cortical regions associated with speech, emotion, and social behavior (107)

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Although over 90% of glutathione exists in the GSH form, a true assessment of total glutathione concentration requires the measurement of both GSH and GSSG