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[DOI] [PMC free article] [PubMed] [Google Scholar] 171.Kashiwaya Y., Takeshima T., Mori N., Nakashima K., Clarke K., Veech R.L

Selective COX-2 inhibitors reduce gastrointestinal damage but may predispose patients to myocardial infarction and thrombosis by decreasing prostacyclin levels

Taken together, these data provide further understanding into the regulation of CBS and in particular into the genetic relationship between DYRK1A and CBS through the Akt/GSK3 and NF-B pathways, which should help develop more effective therapies to reduce cognitive deficits in people with DS

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