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Application of this reagent to the acetate of methyl N -Boc-4-hydroxyprolinate [(2 S ,4 R )- 79 ] gave the protected pyroglutamate 80 which was transformed into dimethyl N -Boc-4-hydroxyglutamate [(2 S ,4 R )- 81 ] (Scheme 20) [82]

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41.4.2 Regulation of Bile Acid Biosynthesis Bile acid biosynthesis is regulated by bile acids, hormones, cytokines, growth factors, oxysterols, xenobiotics, and diurnal rhythm, reflecting the need to tightly control the bodys bile acid load