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In ameliorating IR, it activates the PI3K/AKT signaling cascade, upregulating the mRNA and protein expression of IRS-1 and GLUT4 while downregulating phosphorylated IRS-1 (p-IRS-1 at Ser307), thereby augmenting cellular glucose uptake (151)
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This classification is based on the oxidation state and substitution pattern of the central heterocyclic C-ring (Ibrahim, 2025)
Autophagy (2016) 12(8):14258
Redox Biol 2020, 30: 101413
