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La NAC (N-actylcystine) comme supplment dans les complments alimentaires La N-actylcystine (NAC) est un ingrdient nutraceutique polyvalent ayant de nombreuses indications, qui a t utilis pendant des dcennies en mdecine avant d'tre intgr dans des complments alimentaires dans les annes 1990

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and elevated 4-HNE levels found in both cartilage and synovial fluid of surgically induced canine OA models, where direct intra-articular injection of 4-HNE could replicate the cartilage destruction phenotype, accompanied by significant upregulation of MMP13, ADAMTS5, and cyclooxygenase-2 (COX2) expression (Shi et al., 2014)

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