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Consequently, adjunctive and hostmodulatory strategies have emerged as promising avenues to enhance treatment outcomes, particularly in challenging clinical scenarios involving local (such as deep periodontal pockets, furcation involvement, or sites showing incomplete response to conventional therapy) or systemic challenges (e.g., smokers and individuals with diabetes mellitus)

However, for individuals who require high doses or have difficulty absorbing the vitamin, injections may be a more practical option

Neurology 57, 632638

As detailed above, N1IC cells harbor an altered mitochondrial state with increased mitochondrial and cellular lipid peroxidation as well as increased global ROS production (Figs

these systems drive tripartite activity to defend against ferroptosis [10]

A comprehensive evaluation of the available data is crucial to understand these potential risks and benefits