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Myo-inositol has shown statistically significant (but small) improvements in unwanted hair [29]

The copper chelator trientine binds to copper ions, promoting their excretion and decreasing intracellular copper concentration [292]

Science 307 : 734738 Rachmilewitz D et al

doi: 10.3389/fphar.2025.1578400 Received 17 February 2025 Accepted 08 April 2025 Published 23 April 2025 Volume 16 - 2025 Edited by Irina Ielciu, University of Medicine and Pharmacy Iuliu Hatieganu, Romania Reviewed by Kameswara Rao Badri, Morehouse School of Medicine, United States Junqi Chen, Guangzhou University of Chinese Medicine, China Siying Weng, Ningbo Municipal Hospital of TCM, China Yan Dai, The Affiliated Hospital of Southwest Medical University, China Ning Wang, Dalian University of Technology, China Sara Gamal Ahmed, Minia University, Egypt Updates Copyright 2025 Li, Zou, Zhou, Liu, Tan, Xiang and Yu

Eur J Med Chem, 2018, 158: 16 Acknowledgements This work was supported by the National Natural Science Foundation of China (81801858), China Postdoctoral Science Foundation (2018M641676), and the Applied Basic Research Program of Shanxi Province (201801D221408)

Moreover, the effects of NRF2 activation and antioxidant induction are not limited to specific cells or organs, which could result in systemic side effects