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The key efflux pumps present in the BBB comprise P-glycoprotein (P-gp), the breast cancer resistance protein, and various drug resistance-associated proteins[37]

Mechanistically, intranasally administered agents may be absorbed through the olfactory epithelium or trigeminal nerve endings and transported to the brain via extracellular diffusion and intracellular axonal pathways, which may partially bypass BBB-related constraints (Raghav et al., 2023

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