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doi: 10.3389/fphar.2026.1778496 Received 31 December 2025 Revised 04 February 2026 Accepted 12 February 2026 Published 27 February 2026 Volume 17 - 2026 Edited by Krishna M Boini, University of Houston, United States Reviewed by Wenlong Sun, Shandong University of Technology, China Naciye Yaktubay Dnda, Faculty of Medicine, Cukurova University, Trkiye Updates Copyright 2026 Pi, Yan, Jia, Liu, Tang, Huang, Fang, Shi and Li

Casati, L., Sendra, R., Poletti, A., Negri-Cesi, P

Borthakur G , Garcia-Manero G, Estrov Z, Konopleva M, Burger J, Thomas D, Kadia T, Williams B, George S, Kantarjian H

139, 142, 143 The increased number of blood monocytes in humans and mouse models with CAD results from enhanced proliferation of bone marrow hematopoietic stem and progenitor cells (HSPCs) due to hypercholesterolemia induced lipid raft signaling and ROS production (Figure 3)

But under oxidative stress conditions induced by reactive species, toxins or ARE inducers, the association between Nrf2 and Keap1 is disrupted and Nrf2 translocates to the nucleus of the cell, where it binds to small Maf proteins that increase the transcription of genes driven by ARE [67]

Pharmacological regulation of platelet factors that influence tumor angiogenesis