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& Sieghart, W

Through in vivo and in vitro experiments in PAH rat models, it was found that HIF-1 can regulate mitochondrial dynamics in pulmonary vascular remodeling under hypoxic conditions by directly regulating the expression of dynamin-related protein 1 (Drp1), which in turn can cause hypoxia-induced mitochondrial dysfunction and hypoxia-stimulated PASMCs proliferation and apoptosis, that is, mitochondrial dynamics under hypoxic environment are involved in the remodeling of pulmonary vessels [56]

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Oxidative Med Cell Longev 2018;2018:4120458