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However, deviations from this optimal concentrationeither a reduction or an increasecan effectively impede the progression of HCC

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Accordingly, the downregulation of peroxisomes could suppress ferroptosis through restraining the synthesis of polyunsaturated ether phospholipids (PUFA-ePLs), the substrate of lipid peroxidation, hence transforming the EOC cells from a ferroptosis-sensitive status to resistant
