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Oxidation of cysteines thiol group yields sulfenic (R-SOH), sulfinic (R-SO 2 H), and sulfonic (R-SO 3 H) acids, while carbonylation of arginine, lysine, and threonine, as well as tyrosine nitration, generates protein carbonyls (PCs), established oxidative stress markers (Panella et al., 2025)

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In vivo examination of aluminum neurotoxicity has demonstrated that healthy mice treated with aluminum hydroxide display significant motor deficits and develop pathological features similar to those observed in ALS [62]