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However, after this synthesis is complete, the body has a limited power to convert any form of B12 to another by means of enzymatically removing certain prosthetic chemical groups from the cobalt atom

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This benefits people with low stomach acid (including many people over the age of 50) or those who take acid blockers such as Pepcid or Zantac, or proton pump inhibitors such as Prevacid, or Prilosec, who are at an increased risk for B-12 deficiency