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Particularly, PDE5i, as anti-inflammatory drugs, potentially have the power to revert destabilized cell homeostasis, that is the turning-point where several diseases start from considering the many favorable effects deriving from PDE5i-dependent cGMP stabilization, the clinical exploitation of PDE5i can go undeniably beyond ED, as we addressed here, particularly for cardiac diseases and cancer

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first reported that dietary supplementation of 1 g of l-carnitine given twice daily during 6 months of exercise training led to an increase in muscle l-carnitine levels (total and free) compared to placebo [29]

Therefore, further research is needed not only in astrocytes and neurons, but also in other glial cells in order to fully comprehend taurine metabolism and function in the brain

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