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Methyltransferases transfer a methyl group (CH3) from S-adenosylmethionine (SAMe) to a toxic substance or drug molecule, therefore neutralizing reactive groups, regulating metabolic pathways, and enhancing stability and excretion of toxic metabolites

doi: 10.3389/fimmu.2019.02093 36 PassarelliATucciMMannavolaFFeliciCSilvestrisF
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In particular, the authors used poly(butyl cyanoacrylate)-based micro-bubbles loaded with IONPs that can mediate the BBB penetration