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Participants who injected opioids at baseline had a 3.6-fold higher buprenorphine EC 50 (concentration yielding half of the maximal effect) compared to those who used opioids by non-injectable routes (i.e., 4.3 vs

doi: 10.3389/fphys.2026.1764165 Received 15 January 2026 Revised 29 December 2025 Accepted 19 January 2026 Published 09 February 2026 Volume 17 - 2026 Edited by Khosrow Kashfi, City University of New York, United States Reviewed by Jerzy Beltowski, Medical University of Lublin, Poland John Toscano, Johns Hopkins University, United States Updates Copyright 2026 Hirabayashi, Sasaki, Ohno, Takayama, Yamada and Hanaoka

Transparency about the regulatory status of the treatment : A responsible doctor will clearly explain whether a proposed treatment is HSA-approved for its intended use, or whether it constitutes off-label use, and will document informed consent accordingly

Front Cell Neurosci 9

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The study recognized the importance of vitamin D in the diet to support our central nervous system