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Cancer 148 , 17081716 (2021)

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The tumor microenvironment, characterized by hypoxia, inflammation, and high metabolic activity, is another critical aspect of cancer influenced by oxidative stress [107]

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The kidney sections of the alamandine group did not show any significant histopathological changes However, the histopathological evaluation of the kidneys of DOX-treated animals showed severe tubular degeneration, tubular cast and moderate tubular necrosis