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Although previous studies have recommended starting dose of roxadustat treatment, it is generally recommended that roxadustat is prescribed at the lowest dose needed to improve symptoms attributable to anemia and to avoid red blood cell transfusions ( Because maintaining higher Hb levels and a rapid increase in the Hb levels are risk factors for poor outcomes, clinicians should be aware of Hb overshoot caused by roxadustat in clinical practice

Some works report that methylation is a specific feature of genomic DNA that is not shared with mtDNA (32, 33), while other studies show the presence of methylation also at the level of mtDNA (34, 35, 36)

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Histopathological parameters assessed included neutrophil numbers and neovascularization

doi: 10.1073/pnas.88.12.5242