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The efficacy of low-protein diet, branched-chain amino acids (BCAA), and lactulose are the main modern treatment approaches but are insufficient in most cases

Therefore, the regulatory effects of L-carnitine on miRNA expression suggest that it may act as a molecular modulator, exerting both antioxidant and anti-inflammatory effects

Expression of Na v 1.7 channel is increased in small fibre sensory neurones, in preclinical CIPN models, with increased spontaneous neuronal activity, with similar findings in human dorsal root ganglia in segments affected by CIPN[58]

Additionally, the researchers studied M-CPT I and L-CPT I, which are pivotal enzymes in fatty acid oxidation, present in rat and mouse testes

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