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Low B12 may contribute to fatigue

Typically, the catalytic cysteine is exposed to the solvent, while the resolving cysteine is buried, a pattern that is also observed for GRXC2 and ROXY9 (Supplementary Table 1)

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The stimulation of hypothalamic POMC neurons is inhibited by -endorphin as an opioid reward process is involved in the short-term control of eating [239]

No single enzyme provides the complete picture

The HKL-2000 package (HKL Research Inc., Charlottesville, VA, USA) was used to index, integrate and scale the X-ray diffraction data (Table S2)
