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Sznt M, Gupte R, Kraus WL, Pacher P, Bai P

The reported drugs mainly aim at glutamine transporters, glutaminase, aminotransferases, GSH, and NADPH synthesis (Table 1) (Choi and Park, 2018

PMID: 39 GawrylukA.Cybulska-KlosowiczA.CharzynskaA.ZakrzewskaR.SobolewskaA.KossutM.et al

3-Hydroxybutyrate Regulates Energy Metabolism and Induces BDNF Expression in Cerebral Cortical Neurons
It forms an mtROS-mediated RIPK1RIPK3Drp1 complex that enhances Drp1 translocation to mitochondria, thus triggering necroptosis [90]

Current treatment options for PACS still primarily emphasize managing the symptoms but neglect the underlying cause, such as persistent inflammation, immune dysfunction, and tissue damage
