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Specifically, we provide evidence that endogenous IGF-1 is regulated by miR-483-3p in human NK cells, which then contributes to NK cell cytotoxicity

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Mitochondria affect ferroptosis at the level of the cytosolic iron pool regulation by fine-tuning the iron influx from the cytosol into mitochondria, at the level of electron transport chain by adjusting mitROS generation and oxidative phosphorylation via AMPK activation in the energy-deficient state, and at the level of tricarboxylic acid (TCA) cycle affecting the content of NADPH and GSH [162, 166]
