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They are produced from elements ingested with the diet, metabolized in Trimethylamine by bacteria, and later in TMAO in liver
Trends Endocrinol Metab 22:2433 Tiano JP, Delghingaro-Augusto V, Le May C et al (2011) Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents beta cell failure in rodent models of type 2 diabetes

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The percent abundance of fecal propionate levels was unchanged with housing temperature and genotype (Supplementary Fig
