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ROS, such as superoxide (O 2 - ), can be produced in mitochondrial complexes I and III in components of the tricarboxylic-acid cycle, including -ketoglutarate dehydrogenase (EC 1.2.4.2), and in the outter mitochondrial membrane, damaging cell components such as lipids, proteins and DNA [25, 47]

Although high ROS levels cause cellular damage and dysfunction, a low basal level of ROS is considered advantageous for maintaining cellular proliferation, differentiation, and survival [31, 32]

Targeting the innate repair receptor to treat neuropathy

[DOI] [Google Scholar] 48.Tajik N, Frech M, Schulz O, Schlter F, Lucas S, Azizov V, Drholz K, Steffen F, Omata Y, Rings A, Bertog M, Rizzo A, Iljazovic A, Basic M, Kleyer A, Culemann S, Krnke G, Luo Y, berla K, Gaipl US, Frey B, Strowig T, Sarter K, Bischoff SC, Wirtz S, Caete JD, Ciccia F, Schett G, Zaiss MM

445 Property-based drug design The design of drugs on the basis of their properties involves the meticulous consideration and regulation of molecular and physicochemical attributes to optimize the pharmacological and safety profiles of drug molecules, encompassing their pharmacodynamic, pharmacokinetic, and toxicokinetic properties