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For example, gene therapy for hemophilia results in a 100-fold loss in gene expression per AAV dose ( An alternative strategy to AAV is ATP7B-carying lentiviruses administered into WD mice during gestation

Aggressive: 80 mg loading + 20 mg maintenance = 100 mg total

Less than 30 seconds

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Nature 541(7638):481487 Zhang C, Yu D (2016) Advances in decoding breast cancer brain metastasis

Targeting mitochondrial iron metabolism suppresses tumor growth and metastasis by inducing mitochondrial dysfunction and mitophagy
