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Based on the concepts related to heterogeneous effects, we surmised that the mutual effect might induce allosteric effects, enhancing the binding or releasing of the substrate to SLC7A11, and promote the transport activity and efficiency of System Xc- [16,17]

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doi: 10.1111/j.1398-9995.2009.02257.x

MSC-Exos activate Nrf2/HO-1 expression via the GOT1/CCR2 signaling pathway to prevent ferroptosis, reduce inflammation in OA mice, and improve their performance, providing a potential treatment for OA and other orthopedic diseases