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There is heterogeneity in the precise mechanisms whereby opioid receptors regulate neurotransmitter release, even within any given brain region (Figure 1)

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In response to the damage, mitogenic cyokines are secreted and a similar process to wound healing results in rapid cell cycling and rapid maturation of keratinocytes [1, 2, 3].The constant inflammatory cell chemotaxis and cytokine release causes the chronic clinical course with recurrent lesions

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In addition, loperamide was found to reduce TNF- levels and induce the production of antimicrobial peptides, such as bactericidal/permeability increasing protein and LL37, enhancing hosts ability to fight against M.tb infections while protecting tissues from excessive inflammatory damage [13]
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