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instead, it may activate alternative receptor pathways or cellular mechanisms distinct from IGF-1 axis engagement

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Patten PEM, Buggins AGS, Richards J, Wotherspoon A, Salisbury J, Mufti GJ, et al

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There were, as proofs of the concept (the intracranial (superior sagittal sinus), portal, and caval hypertension, and aortal hypotension were counteracted) in either case, a rapid effect, reduced gross (i.e., brain swelling was rapidly counteracted) and microscopic organs lesions, congestion, and hemorrhage

Scenario 1: Abdominal injection for a patellar tendon injury