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Following HMGB1 inhibition or 5-HT7R knockout, the downstream Nrf2/xCT/GPX4 signaling pathways was upregulated, resulting in alleviated depressive-like behaviors (Du et al., 2025)
This absence of IGF-1 stimulation has been consistently demonstrated across multiple studies and dose ranges
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(2017) 13:e1006621
KadowakiTMaegawaHWatadaHYabeDNodeKMuroharaTet al
Postgrad Med J
