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NP-induced oxidative stress can mainly be divided into two types according to their underlying mechanisms (Horie and Tabei, 2021)

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Since glutaminase 1 (GLS1), a key mitochondrial enzyme that catalyzes the deamidation of glutamine, was first discovered in the kidney in 1958 9 , many enzymes involved in glutamine metabolism have been reported 4

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10.1016/j.addr.2016.06.005 41

Researchers who skip titration steps or escalate doses too quickly experience dramatically worse GI symptoms