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In contrast, when all three genes were simultaneously overexpressed, glucoamylase levels increased to 116% of the WT, and total secretory protein levels increased to 118% of the WT

Published 14 June 2021

DSDimitrovet.al1993305S308

Similarly, in bipolar disorder, particularly during depressive episodes, patients exhibit altered energy metabolism marked by increased lactate levels and decreased glucose and glycine levels, which parallels results in ME/CFS that suggest TCA impairment and energy metabolism dysregulation (Yamano et al., 2016

Alterations in the structure and function of mitochondrial compartments affect mitochondrial homeostasis and quality control (Iovine et al., 2021), which are closely linked to neurological diseases (Figure 1)

[DOI] [PMC free article] [PubMed] [Google Scholar] 109.Riley P.A