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J., Li Y., Nyati M

SPT, a pyridoxal 5-phosphate-dependent enzyme, is the rate-limiting enzyme for SA production [189]

It typically works within 30 minutes and lasts up to 4 hours

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The study found that while both methods were safe, topical administration was more effective at reducing inflammation (inhibition of inflammatory factors such as IL-6, TNF-, and Interferon-gamma) and improving tear stability (Heydari et al., 2023)