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When acting alone, EPA and DHA are highly effective antioxidants, but they can be further augmented in synergism with marine carotenoids like astaxanthin, stimulating the transcription of NAD(P)H quinone dehydrogenase 1 (NQO1), heme oxygenase-1 (HO-1), and glutathione S-transferase Mu 2 (GSTM2), essential in controlling oxidative reactions [41]

however, the pharmacokinetics of the anti-TNF agents might still be altered [188]

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GSB-106 produced a bell-shaped concentrationresponse survival curve in serum-deprived SH-SY5Y cells, which is generally a characteristic of compounds that mimic receptors agonist ligands, capable of homodimerization, mainly of receptors of growth factors, some hormones and cytokines 39,40

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