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The NLRP3 inflammasome in ECs can be caused by stimuli such as low-density lipoprotein oxidized, hyperglycemia, and nicotine, thus leading to the death of ECs [84, 85]

On the other hand, traditional methods of fever reduction (physical, non-pharmacological) look promising and have few side effects

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Loss of estrogen-mediated immunoprotection underlies female gender bias in experimental Crohns-like ileitis

doi: 10.1093/stcltm/szae025, 19

Thus, not only the size but also the charge and shape of the glutathionylated substrate are relevant with GS in GSSG being the optimal leaving group in accordance with a 2nd glutathione-interaction site (Fig