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Smaller injection volumes at higher doses
To ensure unbiased aptamer selection against CspZ via SELEX, the diversity of the initial oligonucleotides library was thoroughly validated and only a minor bias for guanines was observed (greater than 32%)
After that, discard and reconstitute a fresh vial if needed
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Additionally, EGCG effectively suppresses the activity of xanthine oxidase, an enzyme involved in purine catabolism and uric acid formation, thereby mitigating the associated increase in ROS (68)
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