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Additionally, interaction of S100A12 with CacyBP/SIP (Calcyclin binding protein/Siah-1 interacting protein) is via the CD36 (a class B scavenger) receptor (154, 155)

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The hypothesis proposes cells at risk of being driven into the IDO metabolic trap include antigen-presenting cells, serotonergic neurons in the midbrain raphe nuclei, serotonin-producing enterochromaffin cells in the intestinal mucosa, and melatonin-producing pinealocytes

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