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The cell maintains a 10:1 ratio of cytosolic GTP:GDP so exchange for GTP is ensured

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131 Similarly, sinomenine exhibits hepatoprotective effects through suppression of NLRP3 inflammasome activation, reduction of oxidative stress, and inhibition of the HMGB1/TLR4/NF-B pathway

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Post-chemotherapy-persister cells resistant to lapatinib treatment in breast, melanoma, lung, and ovarian cancer have been characterized as GPx4-dependent (63)