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Follow-up studies revealed that the combined deletion of Aldh2 in both the liver and gut raised acetaldehyde concentrations to those measured in global Aldh2 knockouts after alcohol exposure (105)

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How This Works NAD+ is a coenzyme central to redox reactions, energy metabolism (glycolysis, TCA cycle, oxidative phosphorylation), and cellular maintenance pathways including DNA repair and mitochondrial biogenesis [1]

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