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A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer

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However, nephrotoxic doses resulted in reduction of the total lyase activity (MacFarlane et al., 1993)

IBD patients exhibit depleted beneficial bacteria (e.g., butyrate-producing Clostridium ), increased pathogenic bacteria, and reduced SCFAs

By blocking NNMT, the compound is associated with preserved NAD+ levels and reduced fat storage, alongside improvements in cellular energy utilization and insulin sensitivity