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SSZ, an SLC7A11 inhibitor, reduces GSH synthesis by inhibiting cystine uptake, promotes ROS accumulation, triggers ferroptosis, and enhances temozolomide (TMZ) chemosensitivity, creating a synergistic antitumor effect

Perez-Riverol Y, Bandla C, Kundu DJ, Kamatchinathan S, Bai J, Hewapathirana S, et al

CIH also induced hyperglycemia, lipid peroxidation of liver tissue, and increased activity of nuclear factor (NF)-B but not an inflammatory response [as tumor necrosis factor (TNF)- was not detectable], which suggests that CIH induces oxidative stress in the liver

Articles written in the English language and published in peer-reviewed journals were included in the present review

Interestingly, there are observations that immunosuppressive cells, such as MDSCs and Tregs, not only can induce senescence markers in immune cells but also impair their functional competence [154, 155]

We offer a full bioinformatics package including: Site and protein-level annotation Quantitative comparison tables GO/KEGG enrichment of modified proteins Subcellular localization prediction Motif analysis surrounding modification sites Optional protein-protein interaction network mapping All results are provided in user-friendly formats and ready for figure generation