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1 Introduction Parkinsons disease (PD) is a chronic progressive and extensive degenerative disease of the extrapyramidal nervous system that can cause motor symptoms (tremor, muscle rigidity, bradykinesia/slow movements, and postural instability) as well as non-motor symptoms (neuro-vegetative, psycho-cognitive/dementia, pain/sensory, and/or sleep disturbances) ( Parkinsons disease is a multisystem disorder, a consequence of multi-neuropeptidergic dysfunction, which includes dopaminergic, serotoninergic, cholinergic, and noradrenergic systems

Dysregulation of furin may lead to neurodegenerative and neuropsychiatric disorders known to persist during PASC 171,351

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Why this matters: SIRT-1 Downstream Effects Stimulates caloric restriction and exercise pathways through these gene transcription factors:: PGC-1a: The core regulator of mitochondrial biogenesis, PPAR: Regulate fat oxidation, AMPK: Master regulator of cell energy, NF-kB: Inhibition leads to decreased inflammation and oxidative stress Clinical Studies Leucine-Resveratrol Synergy Human Pre-diabetic Subjects Randomized: Leucine 1.1 g + Resveratrol 50mg Twice Daily vs

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