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Since its approval, 13 analogs have been evaluated in clinical trials, but only one, carboplatin, has achieved worldwide acceptance, due to its reduced side-effects, although being less effective, with the clinical standard dosage of carboplatin being a 4:1 ratio compared to cisplatin 23

Supplementary material The Supplementary Material for this article can be found online at: References 1 BeckmanK

Wolters TLC, Netea MG, Hermus A, Smit JWA, Netea-Maier RT

doi: 10.3390/ijms150712895 152

To provide new perspectives from recent advances, this review compares several conventional and advanced strategies for the discovery of wild strains and development of high-producing strains, including isolation and culture-based traditional methods as well as genome mining and directed evolution

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