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Data availability Data is provided within the manuscript

In the muscle atrophy mouse model, Ex-4 also increased muscle mass and muscle fiber size and improved muscle function

In this review, we summarize major historical advances and current knowledge on blood endothelial cell heterogeneity in the brain, and discuss important unsolved questions in the field

Activation of the 3 -AR activates brown adipose tissue thermogenesis, which improves weight loss and energy expenditure

It is a neurotransmitter produced and secreted by the hypothalamus and pituitary glands

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