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Interestingly, various antioxidant agents such as metformin, Nfr2 agonists, Vitamin C and E, resveratrol, as well as different plant extracts have been used in HCC patients and patients at risk of HCC

Endosomal maturation in primary inflammatory cells requires calcium-dependent binding of the sensor Munc13-4 to the late endosomal SNARE syntaxin 7 (STX7) 16 , a fusion modulator, and their binding is essential for endosomal signaling 16

doi: 10.18632/oncotarget.20592

J Pediatr 97:893900 Willard-Mack CL, Koehler RC, Hirata T, Cork LC, Takahashi H, Traystman RJ, Brusilow SW (1996) Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat

doi: 10.1111/j.1523-1755.2002.kid562.x

As an indirect antioxidant, SFN activates the Nrf2/Kelch-like ECH-associated protein 1 (Keap1)/Antioxidant response element (ARE) signaling pathway