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In ALD, ethanol metabolism via hepatocyte CYP2E1 generates excess ROS and acetaldehyde, inducing endoplasmic reticulum stress and mitochondrial dysfunction [365]
& Assis, D
Winkler T
Petersen, B
[DOI] [PMC free article] [PubMed] [Google Scholar] Howden R., Anderson C.R., Goldsbrough P.B., Cobbett C.S
Diagnosis and phenotypic classification of Wilson Disease
