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Previous studies have revealed that PIK3CA mutations reprogram glutamine metabolism by upregulating the expression of glutamate pyruvate transaminase (GPT) 2, thereby increasing glutamine dependency in CRC cells [101]

Additional support for the model of GST regulation is provided by the observations that either immunodepletion of GST , or its inhibition by a rationally designed GSH-based-peptidomimetic inhibitor, - -glutamyl- S -(benzyl)cysteinyl- R ()-phenyl glycine diethyl ester (TLK199), also results in the activation of JNK
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