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A possible explanation for unexpected or contrasting observations is that forcing the plant to overproduce PCs caused a severe GSH depletion, which disables GSH in fulfilling its other important functions in antioxidative defense and signaling

10.1016/j.freeradbiomed.2022.06.232 19 FlohL.ToppoS.OrianL

Burgess, L

A total of 85 patients in the placebo, pemetrexed, and chemotherapy arm received an anti-PD-1/PD-L1 monoclonal antibody at the time of disease progression

2) If so, does normalisation of metabolite levels of the -glutamyl cycle or trans-sulphuration pathway lead to clinically significant improved outcomes for children with autism spectrum disorders