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Cell-sorted studies have revealed widespread methylation shifts in T cells and monocytes, including reproducible changes in CD8+ T cells and distinct profiles relative to CD4+ subsets, indicative of compartment-specific immune methylome remodeling (138-141)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Amoutzopoulos B., Steer T., Roberts C., Cade J.E., Boushey C.J., Collins C.E., Trolle E., de Boer E.J., Ziauddeen N., van Rossum C., et al