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Glutamine prevented genotoxic and clastogenic damages caused by cisplatin in mice (30)

We also observed a positive correlation between RNA expression and chromatin accessibility of loci for many genes expressed in the thyroid gland as exemplified by more closed chromatin at Tg loci and open chromatin at Pax8 loci (Fig 6F)

However, the altered flux of amino acids and their metabolites through transporters, cytosolic pools, MTS and competing pathways when using methionine as the sole source of reducing power might still be more taxing to the cells

Stockwell, et al., "Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.", Cell , 2017 , 171 , 273

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