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The break is part of the protocol
Most notably, domperidonea dopamine receptor antagonist that does not typically cross an intact BBBwas found to exert central behavioral effects in lesioned animals, indicating a functional breach of the barrier (Carvey et al
doi: 10.1186/s40425-018-0339-5
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"Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults." Neurology , 78(17), 1346-1353
